Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome

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Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome.

BACKGROUND Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic and potentially life threatening condition resulting from excessive ovarian stimulation. Reported incidence varies from 1% to 10% of in vitro fertilization (IVF) cycles. The factors contributing to OHSS have not been completely explained. The release of vasoactive substances secreted by the ovaries under human chorionic gonado...

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Does withholding gonadotrophin administration prevent severe ovarian hyperstimulation syndrome?

Withholding gonadotrophin administration (coasting) may prevent severe ovarian hyperstimulation syndrome (OHSS). To ascertain the effectiveness of this protection a cohort of 252 consecutive in-vitro fertilization (IVF) or IVF with intracytoplasmic sperm injection (ICSI) cycles was studied. Twenty women with exaggerated response were treated with coasting. Despite coasting, four patients develo...

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Coasting. A viable option for patients at risk of ovarian hyperstimulation syndrome.

OBJECTIVES To present our experience in 48 coasted patients and how they performed in terms of the number of eggs collected, numbers of embryos available for embryo transfer after in vitro fertilization, pregnant and on going pregnancy rate. METHODS The study was conducted at Lister Hospital, London, United Kingdom, during the period October 1998 through to May 2001. For the purpose of the st...

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Criteria of a successful coasting protocol for the prevention of severe ovarian hyperstimulation syndrome.

BACKGROUND The aim of this study is to report a large series of patients (n = 1223) at risk of developing ovarian hyperstimulation syndrome (OHSS) who underwent coasting. METHODS Coasting started when the leading follicle reached 16 mm and continued until the estradiol (E2) level fell to 3000 pg/ml. RESULTS The E2 level at the start of coasting was (mean +/ SD) 6408 +/- 446 and it fell to 2...

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I-34: New Management Options for Ovarian Hyperstimulation Syndrome

Ovarian Hyperstimulation Syndrome (OHSS) is a rare complication of super ovulation and in vitro fertilization (IVF). Although our understanding of its pathophysiology is incomplete, induction of development of multiple follicles, perturbation of the renin angiotensin system and exposure to luteinizing hormone (LH) or human chorionic gonadotropin (hCG) are essential contributing factors to its d...

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ژورنال

عنوان ژورنال: Cochrane Database of Systematic Reviews

سال: 2017

ISSN: 1465-1858

DOI: 10.1002/14651858.cd002811.pub4